Your Guide To THC-PO: What Is It? What Is It Made Of? Its Effects, Uses, Regulation & More


There are more than a dozen of cannabinoid compounds in the market but THCPO (THC-PO) succeeds in creating a unique legacy for it.

Unlike its precursor THCP, THC-PO is a semi-synthetic cannabinoid.

Its IUPAC name is (6aR,10aR)-3-heptyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydrobenzo[c]chromen-1-yl acetate.

This cannabinoid is synthesized in a laboratory with unique chemical modifications. Due to these modifications, THC-PO exhibits some qualities that are not available to its contemporaries.

In this article, we will be exploring the discovery, effects, side effects, and prospects of THC-PO. We will be also shedding light on the significance of THC-PO in the cannabis community.

Understanding THC-PO

THC-PO is a close relative to THCP.

However, certain modifications are done to the THCP molecule which gives us THC-PO. So, what are these modifications and how are they carried out?

  • The synthesis of THCPO is done by adding an acetate group (‘O’) to THCP. This is executed by carrying out a chemical reaction known as acylation.
  • The interesting part about THC-PO is that it is not found naturally in the cannabis plant. For example, its precursor THCP is found in nature and can be extracted from a cannabis plant.
  • THC-PO is purely synthesized in laboratories by carrying out acylation in THCP. Moreover, it has more stability and potency than THCP making it more powerful and durable in the longer run.
  • The main difference between THC-PO and THC is the number of carbon atoms in their side chain. THC has only a five-carbon side chain, meanwhile, THC-PO has a seven-carbon side chain.
  • Since THC-PO has a superior seven-carbon side chain, it can exhibit higher thermal and oxidative stability than its competitors. This makes it more resistant to degradation, which in turn makes it more durable.

Characteristics of THC-PO

THC-PO was first synthesized in 2021, marking a significant milestone in cannabinoid research. It exhibits certain characteristics that set it apart from other cannabinoids in the industry.

  • THC-PO can bind itself strongly to the CB1 endocannabinoid receptors in the brain. This binding feature can potentially produce more potent psychotropic effects as compared to THC or THCP.
  • Moreover, it is speculated to be 30 times more potent than delta-9 THC. However, the research supporting this statement still needs to be verified by the scientists.
  • Additionally, some researchers suggest that apart from the endocannabinoid system, THC-PO might also be able to bind itself with other neuron receptors in the body. This unique feature of the cannabinoid can lead to diverse effects on the body.

How Does THC-PO Affect The Human Body?

THC-PO is claimed to be one of the strongest cannabinoids available in the market. Therefore, its effect on the human body might last longer than any other cannabinoids variants out there.

  • Recipients can experience strong euphoria and relaxation from THC-PO if taken in mild doses.
  • Potential therapeutic effects such as appetite stimulation and nausea reduction can also be induced by taking THC-PO in mild doses.
  • Since THC-PO is more potent than its contemporaries, new users may avoid consuming it even in mild quantities. This is because these effects may even last up to eight hours.
  • Moreover, experienced cannabinoid users might also find THC-PO overwhelming. Prolonged intake can result in adverse reactions such as anxiety, paranoia, and drowsiness.

THC-PO and Regulation

The legality of THC-PO is still gray in many countries. Therefore, it mostly depends on the local regulations regarding cannabis and cannabinoids.

  • As it has a high potency and serious psychoactive effects, some jurisdictions may regulate or restrict its sale and use.
  • Hopefully, as scientific research on THC-PO advances, these regulations may evolve. This will help in accommodating the medical and recreational use of THC-PO in different parts of the world.

Does THC-PO Have Therapeutic Properties?

There is not enough scientific evidence to support the therapeutic properties of THC-PO. However, as more research emerges regarding this cannabinoid, it will open doors to its use in making people’s lives better.

  • THC-PO just like THC may relieve people from chronic pain, inflammation, nausea, and neurological disorders.
  • Comprehensive clinical trials are still due to confirm these potential benefits. Therefore, we don’t have enough information to determine the optimal dosage and administration methods of THC-PO in different individuals.
  • THC-PO might hold a strong promise for medical applications like THC despite having a lack of research.

In Conclusion

THC-PO is one of the most potent cannabinoids in the market. With its significant implications for both recreational and medical cannabis use, it will have a far greater impact on the cannabis business.

Although not much research has been done on it, the future of THC-PO seems promising due to its unique qualities.

On the brighter side, THC-PO might even become a significant and valuable tool in the treatment of various demanding medical conditions. However, this can be only achieved if rigorous scientific research investigation is carried out on THC-PO for the long term. Until then, users should approach THC-PO products with knowledge, respect, and careful consideration of potential risks.

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