Methoxpropamine Review


Methoxpropamine, also known as MPA, is a synthetic stimulant drug with many unique properties. It’s relatively new, but thanks to its stimulating effects and lack of regulation in many countries, it’s popular among casual drug users. While MPA is still a fairly mysterious drug, it’s gained a following among drug users who seek a new way to enhance their productivity and focus. In this research chemical review, we’ll cover general information about MPA, as well as its history, dosage, administration methods, and effects.

General Information on Methoxpropamine

MPA is a synthetic drug that’s chemically similar to other stimulant drugs like amphetamines (often used to treat ADHD) and cocaine. It has a unique pharmacological profile and is known for inducing stimulating effects that vary in intensity depending on the dosage and mode of administration. So, how does it work? Essentially, it causes dopamine and norepinephrine to build up in the brain, which results in those notable stimulating and euphoric outcomes.MPA is usually in powder form and is often consumed orally, although there are other administration options, which we’ll cover below.

History of Methoxpropamine

Next in our Methoxpropamine review, we’ll go over the history of this research chemical. MPA was first synthesized in 1942 as a possible treatment for depression and other psychiatric disorders. However, it wasn’t until the early 2000s that the drug gained popularity as a recreational drug.

MPA was initially marketed as a research chemical, but it quickly gained a following among drug users who were looking for a new way to enhance their productivity and focus. In 2010, the UK added it to its list of legal highs, and people were able to buy it as a research chemical. So, users seeking legal drugs became customers of MPA, but drug sales now extend past legal limitations.

Dosage and Administration

The dosage and mode of administration of the MPA research chemical seriously affect the drug’s intensity and duration. It’s usually sold as a powder, which can be measured using a scale for accurate dosing. The drug’s dosage can range from 10mg to 60mg or more, depending on the user’s experience and tolerance.

Oral Administration

Oral administration is the most common mode of administering MPA. The drug is usually mixed with water or other liquids and consumed. The onset of effects is slow, taking between 30 minutes to 2 hours, and can last up to 6 hours.

Nasal Insufflation

Nasal insufflation, or “snorting,” is another standard mode of administering MPA. The drug is ground into a fine powder and snorted through the nostrils. This mode of administration has a quicker onset of effects, with effects being felt within 5 to 15 minutes, but the duration of effects is shorter, lasting 2 to 4 hours.


Vaporization means the user heats the drug to a temperature that vaporizes it, and the vapor is inhaled through a device. The onset of effects is quick, taking 1 to 5 minutes, and can last up to 4 hours.


This method involves inserting the drug into the rectum using a suppository. This mode of administration has a slower onset of effects, taking between 30 minutes to 2 hours, but the duration can last up to 6 hours.


Redosing with MPA is possible, but it’s recommended to wait 2 hours or more after the initial dose to prevent an overdose. Redosing too quickly can lead to unwanted side effects, such as anxiety, paranoia, or confusion. Some users experience compulsive redosing, meaning they get an irresistible urge to take more of the drug. Compulsive redosing can be particularly harmful, making it even more vital to use this drug in a safe environment with trusted and sober individuals who can help.

User Methoxpropamine Reviews

User reviews of MPA are generally positive, with many users reporting increased motivation, focus, and productivity. However, some users have reported negative experiences, such as anxiety, paranoia, and confusion. It’s challenging for any given user to predict the effects MPA will have on them.

Onset of Effects

The onset of MPA effects depends on the mode of administration. For instance, oral administration has the slowest onset of effects, while vaporization has the quickest. The average onset is about 30-60 minutes.

Increased Motivation and Concentration

Many users of MPA report higher levels of motivation and focus, making it a popular drug for those looking to enhance their productivity. MPA can help users concentrate at length, making it a popular choice among students, professionals, and athletes.

Additionally, users might feel more analytical and have a sense of thought organization. They may think faster and feel more awake and alert. Another cognitive effect along these lines is an enhanced admiration of music. So, listening to music while on MPA may be particularly stimulating.


MPA can induce a mild sense of euphoria, which can be enjoyable for some users. This feeling is typically described as a sense of well-being. However, MPA has much lower levels of euphoria compared to other amphetamines like cocaine or methamphetamine (meth).

Anticlimax (“Comedown”)

After the peak effects of MPA wear off, users may go through an “anticlimax” or “comedown.” This stage can last several hours or up to 12 hours and might make users feel tired, confused, or anxious. Users may also experience headaches or nausea, and they may feel slower and agitated. Motivation may not only be lost but may also be suppressed.

Potential Side Effects of Methoxpropamine

As with many research chemicals and other substances, Methoxpropamine has potential side effects that users should be well aware of before embarking on their trip. These side effects are as follows:

  • Nausea and vomiting
  • Dizziness and confusion
  • Anxiety and paranoia
  • Headaches and muscle tension
  • Increased heart rate and blood pressure
  • Blurred vision and dilated pupils
  • Impaired motor skills and coordination

Users should be careful with their dosages and avoid redosing too quickly to avoid negative side effects. If you’re considering using this drug after exploring our MPA review, it’s essential to talk to a healthcare professional to discuss potential risks and safe usage. Always use harm reduction practices when administering and experimenting with MPA.

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