O-PCE Review


O-PCE is a powerful dissociative substance that’s gaining popularity among drug enthusiasts. It’s known for producing intense and long-lasting effects, including dissociation, hallucinations, and euphoria. However, as you’ll see, it’s essential to use the substance responsibly and under the guidance of a medical professional to minimize risks. In this article, we’ll take a closer look at O-PCE, including its history, dosage, administration, effects, and potential side effects.

General Information on O-PCE

Let’s begin our O-PCE review with some general information. The O-PCE research chemical, also known as 2′-Oxo-PCE or Deschloroketamine, is a dissociative substance that’s structurally similar to ketamine and PCP. The pharmaceutical company Parke-Davis first created the drug in 1979, but its psychoactive effects were not discovered until much later. O-PCE is a potent NMDA receptor antagonist, meaning it blocks the action of the neurotransmitter glutamate, leading to dissociative effects.

O-PCE is generally sold in a powdered form. It can be administered orally, nasally, or through vaporization. The substance is known for its long-lasting effects, with users reporting effects lasting up to several hours. We’ll go into the effects later on in our research chemical review.

History of O-PCE

Next, let’s go over some history of the O-PCE research chemical. O-PCE was first made in 1979 by the pharmaceutical company Parke-Davis. However, its psychoactive effects weren’t discovered until much later. In the early 2010s, O-PCE began to gain popularity among drug enthusiasts, especially those interested in dissociative substances. Since then, it has become a popular option for other dissociative substances like ketamine.

Dosage and Administration

Whether looking into legal highs or legal drugs, you may have help from medical professionals with dosages. However, if you lack medical oversight, taking the drug with extreme caution is especially critical. O-PCE can be administered orally, nasally, through vaporization, or as a suppository. Dose sizes range from 1mg to 25mg. The appropriate dosage and administration method varies depending on the individual’s tolerance level and desired effects.

Oral Administration

Oral Administration involves ingesting the substance, usually by mixing it with a liquid and swallowing it. The onset of effects is typically slower than other administration methods, but the effects may last longer.

Nasal Insufflation

This method is also known as snorting. It involves crushing the substance into a fine powder and then sniffing it through the nostrils. This method causes a faster onset of effects but might irritate your nasal passages and cause discomfort or even pain.


Vaporization is when you heat the substance to a temperature that vaporizes it, allowing it to be inhaled through a vaporizer or other device. This method is fast-acting and allows for more exact dosing than nasal insufflation.


While redosing is possible, it’s not recommended. It’s risky and may lead to unwanted side effects. Users should not redose the O-PCE research chemical.

User O-PCE Reviews

Reading user reviews of O-PCE might help anyone who’s considering using the substance. That’s because they provide insights into its effects, dosages, and potential risks. Remember, though, these reviews are subjective. So, they may not reflect everyone’s experience with complete accuracy. Therefore, user reviews should be taken with caution and not solely relied upon as a source of information.

Onset of Effects

As with other drugs, the onset of effects for O-PCE varies. The way users experience O-PCE’s effects depends on administration and tolerance. For instance, oral administration takes up to an hour to take effect. Nasal insufflation and vaporization produce effects within minutes.


According to some user reviews, O-PCE can cause euphoric feelings. Users describe them as an increased sense of well-being and pleasure. Further, users report feeling a rush of positive emotions and a sense of contentment.

This euphoric effect is believed to result from the drug’s impact on the brain’s reward system, which regulates the release of dopamine, a neurotransmitter associated with pleasure and reward. O-PCE is thought to increase dopamine release, leading to the euphoric feelings reported by some users.

Visual and Auditory Hallucinations

Hallucinations are one of the primary effects of O-PCE. Visual hallucinations involve seeing things that aren’t present in the environment. Auditory hallucinations involve hearing sounds or voices that do not exist in reality.

The experience of visual and auditory hallucinations can be very different among users. Some may have only mild visual distortions, while others have vivid and intense hallucinations. Similarly, some may only experience minor auditory distortions, while others may hear complex, detailed voices or sounds.

However, hallucinationscan also be potentially dangerous. Users might get disoriented, engage in risky behavior or even experience anxiety and panic. So, it’s best to use O-PCE responsibly and under medical supervision to avoid getting into trouble from hallucinations.


Feelings of detachment from reality, known as dissociation, are another main effect of O-PCE. This ranges from mild to intense, causing confusion and disorientation. Why does this research chemical cause dissociation in users? The effect is the result of O-PCE’s ability to change the brain’s function by blocking NMDA receptors. While some may find this state fascinating, it may also be dangerous.

Anticlimax (“Comedown”)

The comedown from O-PCE may be disagreeable for some users. As the effects fade away, users may experience a sense of disorientation, confusion, and depression. It’s important to take care of oneself during the comedown period and to avoid using the substance again until the effects have completely worn off.

Potential Side Effects of O-PCE

Like any psychoactive substance, O-PCE can produce a range of potential side effects. Some of the most commonly reported side effects include the following:

  • Nausea and vomiting
  • Dizziness and lightheadedness
  • Rapid heart rate and increased blood pressure
  • Sweating and chills
  • Blurred vision
  • Impaired coordination and balance
  • Paranoia and anxiety

To lower the possibility of side effects or other health problems, use the O-PCE research chemical responsibly and find medical advice before using it. As a powerful dissociative substance, O-PCE should be treated with caution and respect.

Related articles

Recent articles