DMXE Review


DMXE, also called Methoxetamine or 3-MeO-2-Oxo-PCE, is a dissociative anesthetic drug that’s structurally similar to ketamine and PCP. The drug is a popular research chemical that’s widely available in the underground market. In this article, we’ll provide a comprehensive review of DMXE, including its general information, history, dosage, effects, user reviews, the onset of effects, potential side effects, and more.

General Information on DMXE

Let’s begin our research chemical review on DMXE with general information. This drug is a chemical compound that belongs to the arylcyclohexylamine class of drugs. It’s also known as Methoxetamine or 3-MeO-2-Oxo-PCE, and generally, it’s not approved for medical use. Further, it’s not available through prescription.

History of DMXE

Next in our DMXE review, we’ll go over the history of this interesting drug. It has a relatively short past compared to other dissociative drugs like ketamine and PCP. It first appeared in the underground market in 2013 and gained popularity quickly due to its similarity to ketamine, which was becoming increasingly difficult to obtain. Since then, DMXE has been widely used as a research chemical and as a recreational drug.

In 2015, the Chinese government banned the production and sale of the DMXE research chemical, along with other research chemicals, in response to the increasing number of drug-related deaths. Generally, this drug is not on national lists of legal drugs. However, despite the ban, DMXE continued to be available on the black market. Its use has continued to spread across the globe.

Dosage and Administration

DMXE is a potent drug, so you should carefully consider its dosage and administration. The drug can be administered orally, nasally, vaporized, or as a suppository. The dosage range for DMXE is typically between 5mg and 30mg, depending on the route of administration and the individual’s tolerance. Remember, it’s not typically on the list of legal highs, so be extra vigilant if you decide to go this route.

Oral Administration

When taken orally, the effects of DMXE can take up to an hour to appear, and they can last for several hours.

Nasal Insufflation

Nasal insufflation or “snorting” DMXE can produce a faster onset of effects, but the duration is shorter.


Vaporizing DMXE produces an immediate onset of effects, but the duration is also shorter than oral administration.


Users should wait at least 3 hours before taking another dose since redosing could be dangerous. Higher doses of DMXE can lead to a range of side effects, including hallucinations, confusion, and loss of consciousness.

User DMXE Reviews

User reviews of DMXE vary widely, with some users reporting positive experiences and others reporting negative experiences. Some users report that DMXE produces a euphoric and relaxing state, while others report feeling anxious and paranoid. Some report experiencing vivid hallucinations and dissociation, while others report feeling numb and disconnected from their surroundings.

Onset of Effects

The onset of effects of DMXE can vary depending on the route of administration. When taken orally, the effects can take up to an hour to appear, and they can last for several hours. When snorted, the effects can appear within 15 minutes, but they can also wear off more quickly. Vaporizing DMXE produces an immediate onset of effects, which can be intense but short-lived.


The euphoric effects of DMXE are thought to be related to the drug’s ability to increase dopamine release in the brain. Dopamine is a neurotransmitter that plays a role in reward and pleasure pathways in the brain. So, when dopamine is released in response to a pleasurable experience, it can produce feelings of euphoria.

DMXE’s euphoric effects have been described as intense and pleasurable. Users report feelings of contentment, relaxation, and heightened sensory perception. Some users report feeling more “at one” with their surroundings and feeling a sense of unity with the world around them.


Users of DMXE often report feeling a sense of dissociation, which can vary in intensity depending on the dose and the individual’s sensitivity to the drug. Some users describe feeling a sense of detachment from their bodies or feeling like they are observing themselves from a distance. Others report feeling like they are in a dreamlike state, where reality seems distorted or surreal.


DMXE can also produce a range of visual and auditory hallucinations, which can contribute to feelings of dissociation. Users may experience vivid and colorful visual imagery or distorted sounds, which can create a sense of being disconnected from reality.

Potential Side Effects of DMXE

As with any psychoactive drug, there are potential side effects associated with the use of DMXE. Some of the potential side effects of DMXE use include the following:

  • Cognitive Impairment: This research chemical may affect memory, attention, and decision-making abilities. Users may have a hard time with tasks that require focus and concentration.
  • Physical Impairment: Potential physical impairments include a loss of coordination, balance, and muscle control. As a result, people on the DMXE research chemical may fall or have other accidents.
  • Respiratory Depression: Respiratory depression can be life-threatening. Users may experience difficulty breathing, shortness of breath, and chest pain.
  • Cardiovascular Effects: Changes in heart rate and blood pressure may result from using this drug. People under the influence may experience palpitations, arrhythmias, and other cardiovascular issues.
  • Gastrointestinal Effects: DMXE can cause gastrointestinal effects like nausea, vomiting, diarrhea, abdominal pain, and discomfort.
  • Renal and Liver Damage: Damage to the kidneys and liver is another potential side effect. Users might encounter kidney failure or liver damage, which can be lethal.
  • Addiction: This drug can be addictive. Over time, people may develop a tolerance to the drug, requiring higher doses to achieve the effects they want. Ultimately, dependent users may experience withdrawal symptoms when they stop using the drug.
  • Overdose: In large doses or when combined with other drugs or alcohol, DMXE can be very dangerous. Users may overdose, which can be life-threatening. Overdosing requires immediate medical attention.

Users must be aware of the risks associated with DMXE use and should seek medical attention if they experience any adverse effects. Use DMXE responsibly and in a safe environment to reduce the risk of harm.

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